Polygalacin D
Polygalacin D
CAS: 66663-91-0
Molecular Formula: C57H92O27
Polygalacin D - Names and Identifiers
Polygalacin D - Physico-chemical Properties
| Molecular Formula | C57H92O27 |
| Molar Mass | 1209.34 |
| Density | 1.54±0.1 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 221-226°C |
| Specific Rotation(α) | -41.5 (c, 1 in MeOH) |
| Solubility | Soluble in water, ethanol, methanol and other solvents, insoluble in petroleum ether, chloroform, ethyl acetate. |
| Appearance | White needle crystal |
| pKa | 12.76±0.70(Predicted) |
| Storage Condition | 4℃冷藏、密封、避光 |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD28009141 |
| In vitro study | Polygalacin D (0-40 µM; 48 hours) inhibits cell proliferation with IC 50 s of 26.49 µM in the A549 cells and 20.52 µM in the H460 cells. Polygalacin D (0-20 µM; 48 hours) increases the proportion of early and late apoptotic cells, and nuclear condensation is observed in A549 and H460 cells. Polygalacin D (0-20 µM; 48 hours) may exerts its apoptotic effects by regulating the apoptotic proteins and the IAP family of proteins in A549 and H460 cells. Cell Proliferation Assay Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM, 40µM Incubation Time: 48 hours Result: Inhibited the proliferation of NSCLC cell lines. Apoptosis Analysis Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Induced apoptosis of NSCLC cell lines. Western Blot Analysis Cell Line: A549 and H460 cancer cell lines Concentration: 10 µM, 20 µM Incubation Time: 48 hours Result: Decreased survivin, c-IAP-1 and c-IAP-2 expression. |
Polygalacin D - Reference
| Reference Show more | 1. Zhang Ling, Guo Xuanxuan, Zhu Li. Distribution and dynamic accumulation of bitter substances in Platycodon grandiflorum [J]. Chinese new drugs and clinical pharmacology, 2019, 030(005):586-591. 2. [IF = 3.205] Chi Zhang et al."Active microbial metabolites study on antitussive and expectorant effects and metabolic has been introduced of platycosides fraction of platycodonis Radix." J Chromatogr B. 2022 Apr;1195:123171 |
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Product Name: Polygalacin D Visit Supplier Webpage Request for quotationCAS: 66663-91-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Polygalacin D Visit Supplier Webpage Request for quotationCAS: 66663-91-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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